Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically found on …
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding ...
Oct 30, 2024 · The scientists next explored how lysosomal function influenced the development of ApoE aggregates within microglia. Both in a cultured microglial cell line and in human iPSC-derived …
Part with PILRA, Power Up Microglia? - ALZFORUM
Jul 19, 2024 · Unlike wild-type microglia, PILRA-less iMG barely changed gene expression in response to interferon-γ or lipopolysaccharide (LPS), suggesting they tone down their response to …
ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
Jul 3, 2025 · Mouse microglia got a genetic tune-up. On 9 June in Nature Aging, researchers led by Warren G. Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing …
Circulating Monocytes Replace Microglia, Border-Associated …
Jun 10, 2025 · Hoping to one day replace dysfunctional microglia, or border-associated macrophages, with specialized cell therapies, scientists are increasingly trying to parse how the origin of a particular …
Over the Span of AD, Roles of Astrocytes and Microglia Change
Microglia, on the other hand, transform from neuroprotectors to slayers only once plaques inundate the brain. In mouse models, where researchers could deplete and restore the cells, microglia polarize …
MS4A4A modifies the risk of Alzheimer disease by regulating lipid ...
Mar 10, 2023 · Michal Schwartz Weizmann Institute of Science Posted: 03 Mar 2023 News: Alzheimer’s Gene MS4A4A Governs the State of Microglia This manuscript provides a new insight to the …
Microglia Build Plaques to Protect the Brain - ALZFORUM
Apr 22, 2021 · Could it be that microglia build plaques rather than bust them? In the April 15 Nature Immunology, researchers led by Greg Lemke at the Salk Institute for Biological Studies, La Jolla, …
CLU alleviates Alzheimer's disease-relevant processes by modulating ...
May 14, 2025 · Lish and 18 colleagues have advanced the role of CLU for three domains of Alzheimer’s: new AD-risk SNPs in the CLU gene that modulate its expression as well as ApoE levels in …