A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to …

Dec 10, 2025 · Monoclonal antibodies can treat autoimmune conditions, cancers and other diseases by working with your immune system.

Bevacizumab (Avastin) is an mAb that targets a protein called VEGF that affects tumor blood vessel growth. It can cause side effects such as high blood pressure, bleeding, poor wound healing, blood …

Jun 3, 2025 · The mAb (ibritumomab) delivers a radioactive substance (Yttrium-90) directly to cancer cells. Another example is Kadcyla, an mAb that is attached to a chemotherapy drug.

Aug 18, 2025 · According to the World Health Organization (WHO), which is responsible for therapeutic mAb nomenclature, over 800 mAb names have been provided [1]. (See 'Naming conventions' below.)

Feb 6, 2025 · FDA-approved mAb treatments have been available since the late 1980s. Monoclonal antibody drugs have proven to be more successful at treating certain diseases, such as some …

The first mAb approved for human use was muromonab-CD3 in 1986, targeting T cells during transplant procedures. Since then, numerous mAbs have been developed, revolutionizing treatments. Today, …

Apr 19, 2023 · A monoclonal antibody (mAb) is a type of immune protein produced in a lab that binds to a specific protein on a cell called an antigen. As with naturally occurring antibodies, monoclonal …

Monoclonal antibodies (mAb) are defined as the antibodies derived from a single clone of plasma cell, all having the same antigen specificity, i.e. produced against a single epitope of an antigen.

The majority of mAb therapeutics are for oncological and immunological/infectious diseases, but these are expanding into other disease areas. Over 100 monoclonal antibodies are in development, and …