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Gram-negative bacteria deploy a range of protein toxins as mediators of inter-bacterial competition and pathogenicity. Among these, colicins comprise a class of ribosomally synthesised bacteriocins ...

Scientists from Cornell University, University of California, San Francisco (UCSF), and elsewhere have found that a surplus of membrane proteins may help bacteria survive antibiotic exposure. These ...

The Tol-Pal complex maintains bacterial outer membrane (OM) stability by regulating lipid homeostasis. (Left) In Gram-negative bacteria, the OM acts as a protective barrier, blocking entry of harmful ...

• Require X (hemin) and/or V (nicotinamide adenine dinucleotide) factors for growth • Responsible for 0.5–1% of all cases of IE • Haemophilus aphrophilus is the most common species responsible for IE ...

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut ...

Lead clinical candidate CTX-187 is a novel antimicrobial immunotherapy developed to treat clinically-prevalent and multi-drug resistant Gram-negative bacterial infections -- Qualified Infectious ...

Researchers report that photodynamic therapy increases antibiotic penetration and disrupts resistance mechanisms in laboratory strains.

Based on the Company's Alphamer® platform, the compound is designed to target serious Gram-negative bacterial infections in the lung, expanding therapeutic options for the most vulnerable patients.