In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin ...

An international study led by the University of Basel has discovered that nuclear pore complexes—tiny gateways in the nuclear membrane—are not rigid or gel-like as once thought. Their interiors are ...

Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus. This microscopic metropolis relies on an intricate ...

At the dawn of complex life, evolution created a container for DNA, its most treasured item. A few billion years later, 20th-century microscopists looked at this container — the nucleus — up close and ...

Siegfried Musser and his team in the Department of Cell Biology and Genetics at the Texas A&M College of Medicine used an advanced imaging technique called MINFLUX to track molecular movements in ...

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers have known that protein quality control and damage to the nuclear ...

Researchers have found that the stability of a protein next to its nuclear localization signal sequence impacts the rate of its entry into the nucleus. Recent research from The Francis Crick Institute ...