Kinases constitute a family of more than 500 enzymes and play critical roles in cellular signaling, both in normal and diseased cells. As a result, kinases continue to be key drug targets, especially ...

As published in Nature Communications, Promega Scientists have developed a NanoLuc-based method for use in drug discovery that measures target residence as a key aspect of target engagement in live ...

A novel nanobody-based immunosensor, designed to function stably in undiluted biological fluids and harsh conditions, has been developed. Their innovative design leverages BRET -- bioluminescence ...

Establishing that a molecule engages with its intended target protein in cells is an essential step in drug discovery and chemical probe development. The term “target engagement” refers to a chemical ...

Engagement of intracellular targets is often critical to drug mechanisms. Establishing a target engagement (TE) profile is an important step in small- molecule drug discovery as well as chemical probe ...

Bioluminescence resonance energy transfer has been long established as the principal method to monitor dynamic protein-protein interactions in living cells. However the application of BRET is in ...

(Nanowerk News) A novel nanobody-based immunosensor, designed to function stably in undiluted biological fluids and harsh conditions, has been developed, as reported by researchers from Science Tokyo.