A study presents evidence that mitochondrial fragmentation is a proximal mechanism underlying ventilator-induced diaphragm dysfunction (VIDD)—and identifies a possible therapeutic to limit diaphragm ...

The gene ECHS1 encodes for enoyl-CoA hydratase short-chain 1, a mitochondrial enzyme involved in branched-chain amino acid and fatty acid metabolism. Rare inherited mutations in the ECHS1 lead to ...

The Agilent Seahorse XF Mito Tox Assay kit is a powerful tool for identifying drug-induced mitochondrial toxicity by directly measuring mitochondrial oxygen consumption rates (OCR). Mitochondrial ...

The Mitochondrial Research Core has standard assays that we provide to assess mitochondrial function. We can also consult on various methods and approaches to assess mitochondrial changes in different ...

Fragmentation and elongation of mitochondria lead to the activation of inflammatory processes in muscle cells, which result in the development of muscle atrophy, and a diminished resistance to ...

Mitochondria turn the food we eat into the energy our cells can use. But when stress hijacks the process they use to maintain their quality, they get snipped into useless fragments and go into a ...

In a recent study published in Nature Metabolism, researchers found that feeding a high-fat diet (HFD) causes mitochondrial dysfunction and fragmentation in white adipocytes in mice. Study: Obesity ...