The enzyme MTH1 is a hot cancer drug target. Spurred in part by a pair of 2014 Nature papers that reported MTH1 inhibitors can kill cancer cells (C&EN, April 7, 2014, page 9), more than 20 industry ...
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation ...
A team of researchers from five Swedish universities has identified a new way of treating cancer. The concept is based on inhibiting a specific enzyme called MTH1, which cancer cells, unlike normal ...
A novel strategy for fighting cancer with potentially minimal side effects could spark a new round of drug discovery efforts. In two new papers, researchers confirm earlier hints that an enzyme called ...
Asthma affects about 300 million people worldwide. Inflammation in asthma may drive irreversible airway remodeling due to subepithelial fibrosis, extracellular matrix degradation and increased smooth ...
Fighting chemotherapy-resistant cancers remains one of the most challenging tasks in the clinic, and the battle is often lost. Artificial nucleoside or nucleobase analogues (antimetabolites) ...
Dr Jamie Scott of AstraZeneca will deliver his BMCS Lectureship Lecture entitled: 'Medicinal Chemistry, Macrocycles and MTH1'. Jamie is the BMCS Lecturer for 2017-2018 and he will be introduced by ...
A team of researchers from five Swedish universities, led by Karolinska Institutet and the Science for Life Laboratory, have identified a new way of treating cancer. The concept is presented in the ...
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