In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Chromosome segregation is the ultimate step in cellular replication. Once genomic DNA is copied, the two sets of chromosomes must separate and each complete set must travel to what will become the two ...

The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint ...

The mammalian diaphanous-related formins (mDIAs), originally characterized for their ability to nucleate unbranched actin, can also regulate microtubule stabilization during cell polarization and ...

“The field has been focused on the role of the Aurora B kinase in phosphorylating kinetochores to help cells fix defective kinetochore-microtubule attachments,” explains Dr. Biggins. In their current ...

Cell division is essential for the correct transmission of genetic information. Each chromosome contains a centromere, a region that plays a central role in controlling chromosome movement during cell ...

This is a preview. Log in through your library . Abstract Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation ...

During mitosis, replicated chromosomes are separated to daughter cells by the microtubule-based mitotic spindle. Chromosomes attach to the mitotic spindle through specialized DNA/protein structures ...