Large-scale protein and gene profiling have massively expanded the landscape of cancer-associated proteins and gene mutations, but it has been difficult to discern whether they play an active role in ...

We know the genes, but not their functions.” To resolve this long-standing bottleneck in microbial research, a joint research ...

Alex Marson of Gladstone and his collaborators at Stanford University developed a genomic mapping technique that helps close ...

A large genetic screen has revealed how stem cells transform into brain cells, exposing hundreds of genes that make this ...

A comprehensive encyclopedia of the known functions of all protein-coding human genes has just been completed and released. Researchers used large-scale evolutionary modeling to integrate data on ...

Could a gene regulatory network in gut microbes have evolved its elaborate and tightly regulated molecular machinery only to pump out antibiotics indiscriminately? Researchers from the Institute of ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

Gene-set analysis seeks to identify the biological mechanisms underlying groups of genes with shared functions. Large language models (LLMs) have shown promise in generating functional descriptions ...

This article was review by Paul Sternberg, PhD from the California Institute of Technology and the Gene Ontology Consortium (GOC). Stay up to date on the latest science with Brush Up Summaries. The ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a ...