PCMT1, long known for its role in protein repair, can also install C-terminal degrons recognized by cereblon (CRBN). This finding links protein repair and degradation through shared chemistry, ...

Prostate cancer remains a leading cause of cancer-related mortality among men worldwide, with its lethality primarily driven by metastatic progression—the main contributor to treatment failure and ...

Shanghai Institute of Materia Medica of the Chinese Academy of Sciences has synthesized molecular glue compounds targeting protein cereblon (CRBN) acting as CRBN/target protein interaction inducers ...

At last week’s American Chemical Society Spring meeting, Bristol Myers Squibb Co. discussed the development of a potent, orally bioavailable and highly selective cereblon (CRBN)-mediated ...