Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by ...

Chromatin is a structure in the cell nucleus that helps pack DNA tightly by wrapping it around proteins called histones. These DNA-protein units, called nucleosomes, control how genes are turned on or ...

The interplay between cellular metabolism and epigenetics has emerged as a major frontier in biomedical research, revealing ...

Chromatin organization influences how genes are activated in our cells and, in turn, how those cells function. In addition to being faster than existing methods for studying chromatin organization, ...

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still ...

Researchers have mapped DNA methylation and 3D genome contacts in the same cells. The atlas uncovers cell-type-specific ...

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, according to a study published in Advanced Science. Inside cells, DNA mixes with ...