Although long thought of as a genetic disease, many cancers do not have genetic lesions but are instead driven by changes in the chromatin, such as changes in the nuclear architecture, dysregulated ...

Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, covalent modifications of core nucleosomal histones, rearrangement of histones, and by RNA ...

Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable states for gene expression and cellular identity. Mutations in these ...

—The gene mutations that drive progression in CML are unclear. A new study found that mutations in activated signaling and myeloid transcription factor genes at diagnosis were associated with worse ...