Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, according to a study published in Advanced Science. Inside cells, DNA mixes with ...

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation. In myelodysplastic ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using ...

The framework of CASHeart. (A) Overview of the data collection and data processing workflow in the CASHeart Database. (B) Introduction to the main interfaces of the CASHeart website. The human heart ...

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend on the ability of chromatin—a mix of DNA and ...

Chronic and viral infections can literally exhaust certain key cells in the immune system from a constant barrage of attacks. But a new pair of papers by scientists at the Hackensack Meridian Center ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics.