Beyond its well-characterized functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damage and has been hypothesized to edit RNA and mediate DNA demethylation.

To our knowledge, this is the first study in fetal ruminants that directly links AID to IPP or to primary antibody formation. mRNA expression of bovine AID and its mutagenic activity has been analyzed ...

Random patterns of deamination by the enzyme activation-induced deoxycytidine deaminase (AID) are the key to generating antibody diversity, a crucial component to a healthy immune system, according to ...

An enzyme crucial to keeping our immune system healthy “surfs” along the strands of DNA inside our cells, scientists have shown for the first time. The researchers used extremely powerful microscopy ...